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robertmiles
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Message 1902 - Posted: 26 Jul 2020, 19:50:03 UTC

Megaphages harbor mini-Cas proteins ideal for gene editing

https://news.berkeley.edu/2020/07/16/megaphages-harbor-mini-cas-proteins-ideal-for-gene-editing/

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Message 1903 - Posted: 28 Jul 2020, 3:43:07 UTC

Autism Gender Bias Explained in Some Cases by Single Amino Acid Change

https://www.genengnews.com/news/autism-gender-bias-explained-in-some-cases-by-single-amino-acid-change/

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Message 1904 - Posted: 28 Jul 2020, 20:41:46 UTC

Genome Guardians Stop and Reel in DNA to Correct Replication Errors

https://news.ncsu.edu/2020/07/genome-guardians/

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Message 1908 - Posted: 2 Aug 2020, 1:50:12 UTC

Neanderthal Genetics May Explain Your Low Tolerance for Pain

https://currently.att.yahoo.com/news/neanderthal-genetics-may-explain-low-130000804.html

robertmiles
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Message 1932 - Posted: 29 Aug 2020, 1:58:12 UTC

WDFY2 Potentiates Hepatic Insulin[url] Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2

https://diabetes.diabetesjournals.org/content/69/9/1887


SGCG rs679482 Associates With Weight Loss Success in Response to an Intensively Supervised Outpatient Program

https://diabetes.diabetesjournals.org/content/69/9/2017

robertmiles
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Message 1982 - Posted: 7 Oct 2020, 2:49:53 UTC

This mentions a gene LRRK2 that is related to Parkinson's:

Coffee may help protect you against Parkinson’s

https://www.ajc.com/life/coffee-may-help-protect-you-against-parkinsons/JCKZCF4CLVCXRJYMAQRSVHGTIQ/

robertmiles
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Message 1983 - Posted: 8 Oct 2020, 0:23:18 UTC

CMT Research Foundation Announces New Research to Study Inflammation as Potential Treatment Target for Charcot-Marie-Tooth Disease

https://cmtrf.org/new-partnership-martini-cmt1b/?utm_source=CMT+Research+Foundation&utm_campaign=2a097ade4b-EMAIL_CAMPAIGN_CMT_Action_Month_Wrap_Care2&utm_medium=email&utm_term=0_62a73085ac-2a097ade4b-213102078

robertmiles
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Message 1985 - Posted: 9 Oct 2020, 0:52:46 UTC

Genome editing!

UC Berkeley’s Jennifer Doudna wins 2020 Nobel Prize in Chemistry

https://news.berkeley.edu/2020/10/07/jennifer-doudna-wins-2020-nobel-prize-in-chemistry/

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Message 1989 - Posted: 10 Oct 2020, 12:24:22 UTC

Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming

https://www.cell.com/current-biology/fulltext/S0960-9822(20)31343-9

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Message 2000 - Posted: 12 Oct 2020, 4:03:29 UTC

BDNF Gene Mutation May Speed Up Memory Loss in Alzheimer's

http://www.physiciansbriefing.com/Article.asp?AID=722341

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Message 2006 - Posted: 14 Oct 2020, 1:17:37 UTC

Genetic Counseling and Testing for Breast Cancer Risk

https://www.cancer.org/cancer/breast-cancer/risk-and-prevention/genetic-testing.html

robertmiles
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Message 2007 - Posted: 15 Oct 2020, 14:39:40 UTC

CMT Research Foundation Launches New Research Project to Design Precision Medicine Approach for Charcot-Marie-Tooth Disease

https://cmtrf.org/new-study-precision-medicine-for-cmt/?utm_source=CMT+Research+Foundation&utm_campaign=d23404f2aa-EMAIL_CAMPAIGN_Lorson-Garcia_101520_Care2&utm_medium=email&utm_term=0_62a73085ac-d23404f2aa-213102078

robertmiles
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Message 2014 - Posted: 17 Oct 2020, 3:35:01 UTC

The ancient Neanderthal hand in severe COVID-19

https://www.sciencedaily.com/releases/2020/09/200930094758.htm


Boy or girl? It's in the father's genes

https://www.sciencedaily.com/releases/2008/12/081211121835.htm


Genomic study reveals evolutionary secrets of banyan tree

https://www.sciencedaily.com/releases/2020/10/201008121248.htm

robertmiles
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Message 2026 - Posted: 21 Oct 2020, 21:20:29 UTC

Furin

https://en.wikipedia.org/wiki/Furin

Aurum
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Message 2034 - Posted: 23 Oct 2020, 15:53:16 UTC - in response to Message 2026.

Furin
https://en.wikipedia.org/wiki/Furin
Very interesting read. Amazing that someone recognized this and published it back in February 2020.

Seems to be a mistake as [13] says SARS-CoV doesn't have the furin cleavage site:
Furin is regulated by cholesterol and substrate presentation. When cholesterol is high, furin traffics to GM1 lipid rafts. When cholesterol is low, furin traffics to the disordered region[16]. This is speculated to contribute to cholesterol and age dependent priming of SARS-CoV.
Also the age-dependent argument seems upside down. As we age cholesterol levels rise. More cholesterol implies more GM1 lipid rafts to sequester furin and so less cleaving of SARS-CoV-2 spike proteins.

Can TN-Grid expand the genes involved in furin and its regultion???

Profile valterc
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Message 2036 - Posted: 23 Oct 2020, 17:06:59 UTC - in response to Message 2034.

I just checked, we have 7 isoforms of the FURIN gene inside our FANTOM db, I just put them on our queue at high priority, you should see them soon floating around.

robertmiles
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Message 2062 - Posted: 7 Nov 2020, 21:37:48 UTC

Digging Deeper into the Role of Genetics in Type 1 Diabetes

https://diabetesresearchconnection.org/genetics-in-t1d/

Profile bozz4science
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Message 2064 - Posted: 9 Nov 2020, 21:29:53 UTC - in response to Message 2036.

7 isoforms of the FURIN gene inside our FANTOM db, I just put them on our queue at high priority
It's great that you as project lead always react to new circumstances rather swiftly! Much appreciated!

Profile bozz4science
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Message 2130 - Posted: 12 Dec 2020, 14:39:59 UTC
Last modified: 12 Dec 2020, 14:40:49 UTC

Hey valterc, I just saw this Reuters article (published 12/11) talking about 5 genes that are currently thought of as potential/partial cause for very severe courses of SARS-CoV-2. The article names the following genes: IFNAR2, TYK2, OAS1, DPP9 and CCR2.

Did we already expand those gene networks or can they skip the queue if not?

Five key genes linked to severe COVID-19 found, suggesting drug targets This research is also published in the journal Nature
Link to the article's abstract
Link to the PDF

robertmiles
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Message 2135 - Posted: 13 Dec 2020, 21:18:12 UTC

Inner Workings: RNA-based pesticides aim to get around resistance problems

https://www.pnas.org/content/early/2020/12/09/2024033117

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